Studies

In the 60’s, the link between our diet and its effect on different populations of bacteria in our gut was established. After more than 60 years of study, we have come to find the benefits of not only probiotics, but pre- and post-biotics as well. Each plays a critical role in the process of keeping your gut healthy. 

In the process, countless studies have shown that health conditions such as IBS, IBD, and inflammation can all be linked with the proper balance of [gut microbiota] and the impact that prebiotic foods have on cholesterol, blood glucose, metabolism, and digestive disorders.

The studies below provide a categorized list and summary of studies and research to explore information to support our well-being.

Research Overview

Health Food Symmetry Pty Ltd (HFS) our Australian partner is a specialty health & medical food supplier that manufactures & researches functional ingredients for the global health and food industries,

HFS claims are backed by University & human clinical studies, Weight loss lifestyle trials, and anecdotal evidence.
HFS is continuing its research designed to demonstrate the health benefits in accordance with food health claims regulation and complementary medicine regulation.

HFS claims are based on extensive evidence in respect to its FDA accredited whole of plant dietary fibre/prebiotic and the health functions it supports:

  • microbiome changes & SCFA synthesis linked to immune support
  • Relief from dietary indigestion & heartburn
  • Natural anti-inflammatory properties,
  • Assistance to bowel movements and digestive experience,
  • Weight loss: due to the GI lowering properties, microbiome, satiety and ghrelin hormone changes backed by a 90-person weight loss study.

Research Focus

HFS has a research focus on human microbiome modulation with several primary areas:

  • Short-Chain Fatty Acid (SCFA) synthesis via fermentation of the dietary fibre/prebiotic “Kfibre” (published paper) and how SCFA’s supports immune function.
  • Acid Reflux (GERD)
    • Patented technology and clinical trials form the basis of this technology.
  • Human Clinical Trial: “Anti-Nausea and appetite improvement during chemotherapy treatment”. Protocols and ethics approval under review (UTAS).
  • Inflammatory Bowel Disease (IBD) & IBS
    • Synbiotic treatments; by co-administration with probiotics to support or amplify the effects. Significant reductions in Disease Activity Index and C-Reactive Protein for two animal models (DSS & Winnie). Paper published 2018.
    • Human Clinical Trial in planning phase
  • Weight loss (study released 2014) via microbiome modulation
  • Other areas of interest;
    • Phytonutrient antioxidants and policosanols
    • microbiome potential: Cholesterol modulation effects, “hunger hormone” changes, and chronic constipation management

happiGut™️ / Kfibre™️ – A Unique prebiotic Fibre

happiGut™️ is the North American name for Kfibre™️ in Australia.

The plant cell wall structure of happiGut™️ / Kfibre™️ is comparable to other fruit and vegetable cellular material but without the levels of accompanying carbohydrate sugars or lipids that are generally present. Fruits and vegetables typically have 1.0-1.8 % (dry weight/wet weight) of fibre.

A 3-gram dose of happiGut™️ / Kfibre™️ has about the same complex fibre content of 166-300 g of fruit or vegetable.

Application of happiGut™️/ Kfibre™️ therefore allows manipulation of levels of cellular fibre in the diet independent of any significant change in energy content. As a supplement to dietary fibre intake, happiGut™️/ Kfibre™️ assists in maintaining a well-balanced diet.

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Microbiome and Gut Health

Yu-Jie Zhang, Sha Li, Ren-You Gan, Tong Zhou, Dong-Ping Xu, Hua-Bin Li (April 7, 2015) "Impacts of Gut Bacteria on Human Health and Diseases" MDPI AG 16.12 (2015): 7493-7519.DOI: 10.3390/ijms16047493

Emanuele Rinninella, Pauline Raoul, Marco Cintoni, Francesco Franceschi, Giacinto Abele Donato Miggiano, Antonio Gasbarrini, Maria Cristina Mele (February 25, 2020) "What is the Healthy Gut Microbiota Composition? A Changing Ecosystem across Age, Environment, Diet, and Diseases." Microorganisms 7.1 (February 25, 2020).

Alexis Mosca, Marion Leclerc, Jean P Hugot (April 12, 2016) "Gut Microbiota Diversity and Human Diseases: Should We Reintroduce Key Predators in Our Ecosystem?" Frontiers in microbiology 7 (April 12, 2016): 455.

Cathy Lordan, Dinesh Thapa, R Paul Ross, Paul D Cotter (June 5, 2020) "Potential for enriching next-generation health-promoting gut bacteria through prebiotics and other dietary components." Gut microbes 11.1 (June 5, 2020): 1-20.

Prebiotics

Cathy Lordan, Dinesh Thapa, R Paul Ross, Paul D Cotter (June 5, 2020) "Potential for enriching next-generation health-promoting gut bacteria through prebiotics and other dietary components." Gut microbes 11.1 (June 5, 2020): 1-20.

Marcel Roberfroid, Glenn R Gibson, Lesley Hoyles, Anne L McCartney, Robert Rastall, Ian Rowland, Danielle Wolvers, Bernhard Watzl, Hania Szajewska, Bernd Stahl, Francisco Guarner, Frederique Respondek, Kevin Whelan, Veronique Coxam, Marie-Jeanne Davicco, Laurent Léotoing, Yohann Wittrant, Nathalie M Delzenne, Patrice D Cani, Audrey M Neyrinck, Agnes Meheust (November 5, 2010) "Prebiotic effects: metabolic and health benefits." The British journal of nutrition 104 Suppl 2 (November 5, 2010): S1-63.

Health Conditions related to and impacted by the microbiome

Herbert Tilg, Alexander R Moschen (September 30, 2014) "Microbiota and diabetes: an evolving relationship." Gut 63.9 (September 30, 2014): 1513-21.

P D Cani, L Geurts, S Matamoros, H Plovier, T Duparc (May 27, 2015) "Glucose metabolism: focus on gut microbiota, the endocannabinoid system and beyond." Diabetes & metabolism 40.4 (May 27, 2015): 246-57.

Andreia M Dias, Gonçalo Cordeiro, Maria M Estevinho, Rui Veiga, Luis Figueira, Marta Reina-Couto, Fernando Magro (July 22, 2020) "Gut bacterial microbiome composition and statin intake-A systematic review." Pharmacology research & perspectives 8.3 (July 22, 2020): e00601.

Hsin-Jung Wu, Eric Wu (August 23, 2012) "The role of gut microbiota in immune homeostasis and autoimmunity." Gut microbes 3.1 (August 23, 2012): 4-14.

Fibre

Kanti Bhooshan Pandey, Syed Ibrahim Rizvi (January 12, 2011) "Plant polyphenols as dietary antioxidants in human health and disease." Oxidative medicine and cellular longevity 2.5 (January 12, 2011): 270-8.

Devinder Dhingra, Mona Michael, Hradesh Rajput, R T Patil (June 5, 2013) "Dietary fibre in foods: a review." Journal of food science and technology 49.3 (June 5, 2013): 255-66.

Barbara A Williams, Lucas J Grant, Michael J Gidley, Deirdre Mikkelsen (June 6, 2018) "Gut Fermentation of Dietary Fibres: Physico-Chemistry of Plant Cell Walls and Implications for Health." International journal of molecular sciences 18.10 (June 6, 2018).

Hannah D Holscher (August 29, 2017) "Dietary fiber and prebiotics and the gastrointestinal microbiota." Gut microbes 8.2 (August 29, 2017): 172-184.

Kanti Bhooshan Pandey, Syed Ibrahim Rizvi (January 12, 2011) "Plant polyphenols as dietary antioxidants in human health and disease." Oxidative medicine and cellular longevity 2.5 (January 12, 2011): 270-8.

Gut and Immunity

Parisa Shokryazdan, Mohammad Faseleh Jahromi, Bahman Navidshad, Juan Boo Liang (March 22, 2017) "Effects of prebiotics on immune system and cytokine expression." Medical microbiology and immunology 206.1 (March 22, 2017): 1-9.

Malkanthi Evans, Stuart Reeves, Larry E Robinson (August 23, 2012) "A dried yeast fermentate prevents and reduces inflammation in two separate experimental immune models." Evidence-based complementary and alternative medicine : eCAM 2012 (August 23, 2012): 973041.

Markus B Geuking, Yasmin Köller, Sandra Rupp, Kathy D McCoy (May 19, 2015) "The interplay between the gut microbiota and the immune system." Gut microbes 5.3 (May 19, 2015): 411-8.

Lucia M Kato, Shimpei Kawamoto, Mikako Maruya, Sidonia Fagarasan (January 29, 2015) "The role of the adaptive immune system in regulation of gut microbiota." Immunological reviews 260.1 (January 29, 2015): 67-75.

Jacek Karczewski, Barbara Poniedziałek, Zygmunt Adamski, Piotr Rzymski (July 13, 2015) "The effects of the microbiota on the host immune system." Autoimmunity 47.8 (July 13, 2015): 494-504.

Short Chain Fatty Acids

O C Velázquez, H M Lederer, J L Rombeau (December 12, 1997) "Butyrate and the colonocyte. Production, absorption, metabolism, and therapeutic implications." Advances in experimental medicine and biology 427 (December 12, 1997): 123-34.
PMID: 9361838

Maayan Levy, Eran Blacher, Eran Elinav (January 11, 2018) "Microbiome, metabolites and host immunity." Current opinion in microbiology 35 (January 11, 2018): 8-15.

Jiezhong Chen, Luis Vitetta (May 15, 2020) "The Role of Butyrate in Attenuating Pathobiont-Induced Hyperinflammation." Immune network 20.2 (May 15, 2020): e15.

L K Brahe, A Astrup, L H Larsen (September 22, 2014) "Is butyrate the link between diet, intestinal microbiota and obesity-related metabolic diseases?" Obesity reviews : an official journal of the International Association for the Study of Obesity 14.12 (September 22, 2014): 950-9.

Knud Erik Bach Knudsen, Helle Nygaard Lærke, Mette Skou Hedemann, Tina Skau Nielsen, Anne Krog Ingerslev, Ditte Søvsø Gundelund Nielsen, Peter Kappel Theil, Stig Purup, Stine Hald, Anne Grethe Schioldan, Maria L Marco, Søren Gregersen, Kjeld Hermansen (February 1, 2019) "Impact of Diet-Modulated Butyrate Production on Intestinal Barrier Function and Inflammation." Nutrients 10.10 (February 1, 2019).

João P B Silva, Kely C Navegantes-Lima, Ana L B Oliveira, Dávila V S Rodrigues, Sílvia L F Gaspar, Valter V S Monteiro, Davi P Moura, Marta C Monteiro (December 18, 2019) "Protective Mechanisms of Butyrate on Inflammatory Bowel Disease." Current pharmaceutical design 24.35 (December 18, 2019): 4154-4166.